Recombinant Human Bone Morphogenetic Protein-7
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta of signaling proteins and were originally identified as protein regulators of cartilage and bone formation, BMP-7 being the most potent osteoconductive factor. They have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Exogenous BMP-7 promotes enhanced production of collagen type-II, aggrecan and hyaluronan. It can counteract interleukin-1 on human articular chondrocytes and is thought to maintain normal chondrocyte homeostasis. BMP-7 is synthesized as large precursor molecule which are cleaved by proteolytic enzymes. The active form can be found as homodimers or heterodimers.
| Catalog No. | 108-07 |
|---|---|
| Country of Manufacture | China |
| Product Code | rhBMP-7 |
| Size/Quantity | 2ug, 10ug, 1mg |
| Product use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Dry ice. |
| Synonyms | OP-1 (osteogenic protein 1) |
| AA Sequence | STGSKQRSQN RSKTPKNQEA LRMANVAENS SSDQRQACKK HELYVSFRDLGWQDWIIAPE GYAAYYCEGE CAFPLNSYMN ATNHAIVQTL VHFINPETVPKPCCAPTQLN AISVLYFDDS SNVILKKYRN MVVRACGCH |
| Source | Escherichia coli |
| Molecular Weight | Approximately 15.6 kDa, a monomeric, non-glycosylated polypeptide chain containing 139 amino acids. |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in 30% acetonitrile, 0.1% TFA. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. |
No Publication available at this time.