Explore Liver Regeneration and Fibrosis with ScienCell's Hepatic Stellate Cells
Hepatic stellate cells (HSCs) are essential to liver function, playing a central role in homeostasis, extracellular matrix maintenance, repair, and regeneration. ScienCell Research Laboratories provides high-quality primary human hepatic stellate cells (HHSteC) to support cutting-edge research into liver disease pathogenesis and therapeutic development.
Hepatic Stellate Cells: A Key Player in Liver Health and Disease
In a healthy liver, HSCs maintain extracellular matrix integrity, regulate microcirculation, and store vitamin A. However, following liver injury, these cells undergo activation, transforming into myofibroblast-like cells and becoming the primary source of type I collagen in fibrotic tissue. Activated HSCs contribute to hepatic inflammation, fibrosis, and intrahepatic portal hypertension, making them a critical focus for studies on liver disease progression and treatment.
Recent research highlights the heterogeneity of activated HSCs, revealing distinct populations with proliferative, inflammatory, or fibrogenic properties. Understanding the molecular regulation of HSC activation is key to developing novel therapeutic strategies for hepatic fibrosis, potentially reducing morbidity and mortality in patients with chronic liver conditions.
Premium-Quality HHSteC for Reliable Research:
ScienCell’s HHSteC are derived from human liver tissue and meticulously characterized to ensure reliability and reproducibility in research applications. Each vial contains more than 5 x 10^5 cells in 1 mL of volume, cryopreserved at passage one to maintain optimal viability and function.
Our HHSteC are:
- Verified via immunofluorescence for α-smooth muscle actin expression
- Free from contaminants, including HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi
- Guaranteed to expand for up to 15 population doublings under ScienCell-provided conditions
Advance Your Research with ScienCell’s HHSteC
With their pivotal role in liver disease mechanisms and regeneration, HHSteC provide an invaluable tool for investigating liver fibrosis, inflammation, and therapeutic interventions. Whether studying hepatic microcirculation, fibrotic progression, or regenerative medicine, ScienCell’s HHSteC offer the precision and quality necessary for groundbreaking discoveries.
